ODCs

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1 OMIM reference -
4 associated genes
8 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
6 signs/symptoms

Epidermolytic palmoplantar keratoderma

Keratoderma hereditarium mutilans with ichthyosis


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	KRT1	(0.75)	LOR

Citations in the biomedical literature:

Epidermolytic palmoplantar keratoderma		Keratoderma hereditarium mutilans with ichthyosis
	Synonym(s): - Diffuse erythrodermic palmoplantar keratoderma, Voerner type - Diffuse erythrodermic palmoplantar keratoderma, VÃ¶rner type - EPPK - Epidermolytic palmoplantar keratoderma of Voerner - Epidermolytic palmoplantar keratoderma of VÃ¶rner		Synonym(s): - Camisa disease - Keratoderma - ichthyosiform dermatosis - elevated beta-glucuronidase - Loricrin keratoderma - Vohwinkel syndrome - ichthyosis

	Classification (Orphanet): - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: (no data available)		Epidemiological data: (no data available)

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Palmoplantar hyperkeratosis / keratoderma

Epidermolytic palmoplantar keratoderma		Keratoderma hereditarium mutilans with ichthyosis
	Very frequent - Autosomal dominant inheritance - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Warts / papillomas Frequent - Abnormal fingernails - Eczema - Hyperhidrosis / increased sweating		Very frequent - Ichthyosis / ichthyosiform dermatitis Occasional - Auto-aggressivity / auto-mutilation - Hypertonia / spasticity / rigidity / stiffness - Motor deficit / trouble - Nails anomalies